Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.40 |
| ▸ | S100A10 | P60903 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153970 | 0.98 | MAOA (0.42) | MAOAMAOBHTR2CHTR6PLA2G1B | |
| SCHEMBL941988 | 0.89 | CA12 (0.45) | MAOAMAOBANXA2S100A10CYP3A4 | |
| SCHEMBL7194593 | 0.86 | MAPK1 (0.58) | MAOAMAOBANXA2S100A10CYP3A4 | |
| SCHEMBL7184508 | 0.85 | ANXA2 (0.41) | MAOAHTR2CHTR6ANXA2S100A10 | |
| SCHEMBL6570987 | 0.82 | CYP3A4 (0.38) | MAOAMAOBANXA2S100A10CYP3A4 | |
| SCHEMBL30398364 | 0.81 | MAOA (0.47) | MAOAMAOBHTR2CHTR6PLA2G1B | |
| SCHEMBL6366825 | 0.81 | MAOA (0.47) | MAOAMAOBHTR2CHTR6PLA2G1B | |
| SCHEMBL11354311 | 0.80 | GCK (0.47) | MAOAMAOBHTR2CHTR6PLA2G1B | |
| SCHEMBL11662078 | 0.76 | MAOA (0.43) | MAOAMAOBHTR2CHTR6RHEB | |
| SCHEMBL20727283 | 0.76 | BCL2 (0.50) | MAOAMAOBHTR2CHTR6PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-B1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-6369273-B1 | ARYL ALCOHOLS OR ESTERS FOR ELEVATION OF PYRUVATE DHYDROGENASE | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |
| US-4331817-A | SULFIDING IN THE PRESENCE OF HALOGENS | MINNESOTA MINING AND MANUFACTURING CO. (US) | 1982-05-25 | — | — | US | disclosed |