Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28392437 | 0.97 | HSD11B1 (0.54) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| SCHEMBL20146430 | 0.91 | RARB (0.50) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| SCHEMBL35867 | 0.86 | HSD11B1 (0.61) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| SCHEMBL5599432 | 0.86 | HSD11B1 (0.61) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| Hydrogen Sulfide SCHEMBL28025844 | 0.84 | HSD11B1 (0.59) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| Phosphine SCHEMBL27456116 | 0.84 | HSD11B1 (0.59) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| Hydrogen Sulfide SCHEMBL27798487 | 0.84 | HSD11B1 (0.59) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| Phosphine SCHEMBL27545611 | 0.84 | HSD11B1 (0.59) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| SCHEMBL29939361 | 0.84 | HSD11B1 (0.63) | RARBHSD11B1HSD17B10ALDH1A1ESR1 | |
| SCHEMBL23527409 | 0.81 | HTR2A (0.50) | RARBHSD11B1HSD17B10ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907347-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | Arcadia Pharmaceuticals Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009083-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2007-01-18 | — | — | WO | disclosed |