Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608750 | 0.84 | GRM5 (0.56) | GRM5SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1904281 | 0.74 | GRM5 (0.71) | GRM5 | |
| SCHEMBL4609869 | 0.73 | GRM5 (0.49) | GRM5CYP1A2 | |
| SCHEMBL4610103 | 0.73 | GRM5 (0.59) | GRM5IDO1LMNADRD2DRD4 | |
| SCHEMBL4609268 | 0.72 | MAPK1 (0.42) | CHRM4HTR2COPRM1 | |
| SCHEMBL4610798 | 0.72 | GRM5 (0.54) | GRM5DRD2DRD4HRH2 | |
| SCHEMBL4610110 | 0.71 | GRM5 (0.42) | GRM5SLC6A4IDO1SLC6A2SLC6A3 | |
| SCHEMBL4610088 | 0.71 | SLC6A2 (0.43) | GRM5SLC6A4CHRM1CNR1DRD4 | |
| SCHEMBL4609680 | 0.71 | GRM5 (0.59) | GRM5SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4610865 | 0.70 | IDO1 (0.42) | GRM5SLC6A4IDO1DRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |