Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901764 | 0.75 | GRM5 (0.71) | GRM5ROCK2PRKG1 | |
| SCHEMBL4609669 | 0.73 | GRM5 (0.56) | GRM5 | |
| SCHEMBL4608750 | 0.73 | GRM5 (0.56) | GRM5 | |
| SCHEMBL4610030 | 0.73 | GRM5 (0.43) | GRM5CYP1A2 | |
| SCHEMBL4608995 | 0.70 | GRM5 (0.45) | GRM5ROCK2PRKG1 | |
| SCHEMBL4608127 | 0.70 | GRM5 (0.41) | GRM5 | |
| SCHEMBL4155422 | 0.67 | GRM5 (0.47) | GRM5 | |
| SCHEMBL4608859 | 0.67 | GRM5 (0.48) | GRM5CYP1A2 | |
| SCHEMBL4608986 | 0.66 | HRH3 (0.40) | GRM5 | |
| SCHEMBL1904664 | 0.66 | GRM5 (1.00) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |