Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4610173 | 1.00 | ALDH1A1 (0.64) | ALDH1A1HRH3KDM4ELTA4HMAPT | |
| SCHEMBL24522256 | 0.84 | HRH3 (0.71) | ALDH1A1HRH3KDM4ELTA4HMAPT | |
| SCHEMBL16480464 | 0.84 | ALDH1A1 (0.66) | ALDH1A1HRH3KDM4ELTA4HMAPT | |
| SCHEMBL1938671 | 0.83 | HRH3 (0.74) | HRH3 | |
| SCHEMBL1938673 | 0.83 | HRH3 (0.74) | HRH3 | |
| SCHEMBL4770791 | 0.83 | ALDH1A1 (0.64) | ALDH1A1HRH3KDM4ELTA4HMAPT | |
| SCHEMBL3562026 | 0.83 | ALDH1A1 (0.90) | ALDH1A1HRH3KDM4ELTA4HMAPT | |
| SCHEMBL13291354 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HRH3KDM4ELTA4HPOLB | |
| SCHEMBL1357166 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HRH3KDM4ELTA4HPOLB | |
| SCHEMBL3355426 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HRH3KDM4ELTA4HPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |