Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590739 | 0.91 | GRM2 (0.38) | GRIN2BGRIN1GRM5NPC1RAB9A | |
| SCHEMBL4591010 | 0.91 | PLA2G7 (0.41) | GRIN2BGRIN1GRM5PLA2G7NPC1 | |
| SCHEMBL4591062 | 0.83 | NPC1 (0.42) | PLA2G7NPC1RAB9A | |
| SCHEMBL4590069 | 0.83 | NPC1 (0.42) | GRM5PLA2G7NPC1RAB9A | |
| SCHEMBL4590755 | 0.82 | GRM2 (0.44) | PLA2G7NPC1RAB9A | |
| SCHEMBL4590528 | 0.81 | NPC1 (0.46) | PLA2G7NPC1RAB9A | |
| SCHEMBL4590958 | 0.79 | GRM2 (0.47) | CXCR3 | |
| SCHEMBL4591441 | 0.78 | NPC1 (0.40) | PLA2G7NPC1RAB9A | |
| SCHEMBL4590135 | 0.78 | ESR1 (0.39) | PLA2G7NPC1RAB9ACLK4 | |
| SCHEMBL4591304 | 0.77 | KDM1A (0.37) | PLA2G7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899321-A1 | HETEROARYL-SUBSTITUTED AMIDES COMPRISING A SATURATED LINKER GROUP, AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000246-A1 | HETEROARYL-SUBSTITUTED AMIDES COMPRISING A SATURATED LINKER GROUP, AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |