Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 19/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937634 | 0.94 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2937290 | 0.94 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3231023 | 0.94 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3238654 | 0.94 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL4611275 | 0.93 | PTGER4 (0.59) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947720 | 0.93 | PTGER4 (0.56) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL8514217 | 0.93 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL10305428 | 0.91 | PTGER4 (0.53) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL8515162 | 0.89 | PTGER4 (0.54) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL9947697 | 0.86 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| EP-1979316-B1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |
| EP-1979316-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007088190-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |