Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 17/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947697 | 0.93 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL9947768 | 0.93 | PTGER4 (0.51) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL4610403 | 0.93 | PTGER4 (0.64) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL12011119 | 0.90 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6ALDH1A1HPGD | |
| SCHEMBL3966058 | 0.90 | PTGER4 (0.54) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2926910 | 0.89 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL3045431 | 0.89 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6ALDH1A1HPGD | |
| SCHEMBL3238654 | 0.87 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL3231023 | 0.87 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL2937290 | 0.87 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| EP-1979316-B1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |