Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2798384 | 1.00 | PDGFRB (0.46) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL4926567 | 0.98 | PDGFRB (0.46) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2797258 | 0.94 | AURKA (0.48) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL3428927 | 0.92 | AURKA (0.49) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL4923895 | 0.90 | PDGFRB (0.42) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2800763 | 0.88 | AURKA (0.49) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL4923004 | 0.87 | AURKA (0.51) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2797899 | 0.87 | AURKA (0.47) | PDGFRBCSF1RKITPDGFRAAURKA | |
| Hydrochloric Acid SCHEMBL2800072 | 0.86 | AURKA (0.47) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL4924647 | 0.86 | AURKA (0.49) | PDGFRBCSF1RKITPDGFRAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979344-A2 | N-(2,3-DIFLUOROPHENYL)-2-[4-({7-METHOXY-5-[(2R)-PIPERIDIN.-2-YLMETHOXY]QUINAZOLIN-4-YL}AMINO)-1H-PYRAZOL-1-YL]ACETAMIDE AND N-(2,3-DIFLUOROPHENYL)-2-[4-({7-ETHOXY-5-[(2R)-PIPERIDIN.-2-YLMETHOXY]QUINAZOLIN-4-YL}AMINO)-1H-PYRAZOL-1-YL]ACETAMIDE FOR USE IN THE TREATMENT OF DISEASE | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |