SCHEMBL4611238

SCHEMBL4611238

COc1ccc(C(=O)Nc2ccc(C(N)=O)cc2)cc1N

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.63
KMT2A Q03164 3/20 0.63
ALDH1A1 P00352 4/20 0.58
PKM P14618 3/20 0.58
LMNA P02545 1/20 0.58
HTT P42858 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
TP53 P04637 1/20 0.56
BCAT2 O15382 1/20 0.55
NQO2 P16083 1/20 0.54
CASP3 P42574 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
KDM4E B2RXH2 1/20 0.54
MAPT P10636 1/20 0.54
USP2 O75604 1/20 0.54
PLAU P00749 4/20 0.53
PLAT P00750 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11147327 0.89 POLB (0.63) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL17507452 0.89 KMT2A (0.59) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL6809736 0.89 NPC1 (0.60) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL6818005 0.89 NPC1 (0.68) MEN1KMT2AALDH1A1LMNAHTT
SCHEMBL11592458 0.87 KMT2A (0.69) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL6813395 0.87 HDAC8 (0.64) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL6813064 0.87 NPC1 (0.58) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL610530 0.87 MEN1 (0.72) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL29440797 0.87 MEN1 (0.72) MEN1KMT2AALDH1A1PKMLMNA
SCHEMBL16129641 0.85 MEN1 (0.66) MEN1KMT2AALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6548647-B2 Spraying coupling components in solution or suspension to collide in reactor chamber, then pressurizing to remove; useful for offset printing inks CLARIANT GMBH (DE) 2003-04-15 US claimed
US-20020055619-A1 Process for preparing azo colorants CLARIANT GMBH 2002-05-09 US claimed
EP-1195411-A1 Process for the preparation of azo colourants Clariant GmbH (DE) 2002-04-10 EP claimed
EP-1417264-B1 NOVEL AZO PIGMENTS CLARIANT PRODUKTE DEUTSCHLAND (DE) 2008-10-15 EP disclosed
US-7318863-B2 Azo pigment preparations for packaging gravure and flexographic printing CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) 2008-01-15 US disclosed
US-7309389-B2 Preparation of azo colorants in microreactors and their use in electrophotographic toners and developers, powder coatings, ink jet inks and electronic medias CLARIANT FINANCE (BVI) LIMITED (VG) 2007-12-18 US disclosed
US-20070213516-A1 Process For Producing High-Purity Azo Dyes HOELLEIN VOLKER 2007-09-13 US disclosed
US-20070204762-A1 Azo Pigment Preparations for Packaging Gravure and Flexographic Printing CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) 2007-09-06 US disclosed
CN-1942529-A Process for preparing high-purity azo colorants CLARIANT GMBH (DE) 2007-04-04 CN disclosed
US-7135266-B2 Preparation of azo colorants in microreactors and their use in electrophotographic toners and developers, powder coatings, ink jet inks and electronic medias CLARIANT FINANCE (BVI) LIMITED (VG) 2006-11-14 US disclosed
US-20060228640-A1 Preparation of azo colorants in microreactors and their use in electrophotographic toners and developers, powder coatings, ink jet inks and electronic medias CLARIANT FINANCE (BVI) LIMITED 2006-10-12 US disclosed
EP-1195411-A1 Process for the preparation of azo colourants Clariant GmbH (DE) 2002-04-10 EP disclosed
US-20010029294-A1 Preparation of azo colorants in microreactors CLARIANT INTERNATIONAL LTD. 2001-10-11 US disclosed
WO-2001059013-A1 METHOD FOR PRODUCTION OF AZO DYES IN MICROREACTORS CLARIANT INTERNATIONAL LTD (CH) 2001-08-16 WO disclosed
US-6271380-B1 TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC, NEUROLOGICAL DISORDERS AS WELL IMMUNOLOGICAL, CARDIOVASCULAR OR HEART-RELATED DISEASES AND COLONIC HYPERSENSITIVITY ASSOCIATED WITH PSYCHOPATHOLOGICAL DISTURBANCE AND STRESS. DUPONT PHARMACEUTICALS COMPANY 2001-08-07 US disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
US-5493011-A PIGMENTING HIGH MOLECULAR WEIGHT NATURAL OR SYNTHETIC ORGANIC MATERIALS HOECHST AG (DE) 1996-02-20 US disclosed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 EP disclosed
US-5026831-A Water-insoluble disazo colorants having hetero-bicyclic methylene-active compounds as coupling component HOECHST AKTIENGESELLSCHAFT (DE) 1991-06-25 US disclosed
EP-0316649-A2 Water insoluble azo colouring agents, their preparation and use HOECHST AKTIENGESELLSCHAFT (DE) 1989-05-24 EP disclosed