Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179962 | 0.84 | DHODH (0.58) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6168326 | 0.84 | DHODH (0.58) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL4611740 | 0.84 | DHODH (0.58) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL496596 | 0.82 | KDM4C (0.54) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL8826118 | 0.81 | KDM4E (0.75) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL14399048 | 0.81 | DHODH (0.55) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6168145 | 0.81 | KDM5B (0.66) | DHODHMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL2946120 | 0.80 | DHODH (0.54) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL18691447 | 0.80 | MEN1 (0.56) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL495687 | 0.80 | DHODH (0.54) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-A1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007090752-A1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-16 | — | — | WO | disclosed |