Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461247 | 1.00 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461250 | 1.00 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL470583 | 0.90 | GPR119 (0.47) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461158 | 0.89 | GPR119 (0.50) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461160 | 0.89 | GPR119 (0.50) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461159 | 0.89 | GPR119 (0.50) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461087 | 0.87 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461086 | 0.87 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461089 | 0.87 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL461135 | 0.83 | GPR119 (0.61) | GPR119GPR183KCNH2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |