Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611618 | 0.90 | PDE4B (0.47) | CNR1ALDH1A1NPSR1PDE4BDGAT1 | |
| SCHEMBL4247698 | 0.82 | CNR1 (0.59) | CNR1CNR2 | |
| SCHEMBL4612821 | 0.82 | LPAR5 (0.42) | CNR1LPAR5CNR2 | |
| SCHEMBL4613060 | 0.81 | MDM2 (0.47) | CNR1MDM2MCL1LPAR5CNR2 | |
| SCHEMBL4612523 | 0.80 | CNR1 (0.57) | CNR1CNR2 | |
| SCHEMBL4611371 | 0.79 | CNR1 (0.51) | CNR1CYP19A1CNR2 | |
| SCHEMBL4633677 | 0.78 | PDE4B (0.52) | CNR1L3MBTL1ALDH1A1NPSR1PDE4B | |
| SCHEMBL4910813 | 0.78 | PDE4B (0.54) | CNR1ALDH1A1NPSR1PDE4BPDE4A | |
| SCHEMBL700719 | 0.77 | CNR1 (0.58) | CNR1PDE4BCYP19A1CNR2 | |
| SCHEMBL4599839 | 0.77 | L3MBTL1 (0.66) | LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910331-A1 | PYRAZOLE DERIVATIVES AS CBl MODULATORS | AstraZeneca AB (SE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007010217-A1 | PYRAZOLE DERIVATIVES AS CBl MODULATORS | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | WO | disclosed |