SCHEMBL4613461

SCHEMBL4613461

O=C(Nc1ccc2ccccc2c1)[C@@H]1CCCN1C(=O)OCc1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.73
ALDH1A1 P00352 3/20 0.72
TSHR P16473 2/20 0.72
KDM4E B2RXH2 1/20 0.72
LMNA P02545 1/20 0.72
HSD17B10 Q99714 1/20 0.68
KDM1A O60341 1/20 0.67
RCOR1 Q9UKL0 1/20 0.67
TP53 P04637 1/20 0.63
GFER P55789 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.61
KMT2A Q03164 2/20 0.60
MEN1 O00255 1/20 0.60
CTRB1 P17538 1/20 0.57
KLK7 P49862 1/20 0.55
POLB P06746 1/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4389585 0.90 NPSR1 (0.66) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL4389580 0.90 NPSR1 (0.66) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL7265734 0.88 KDM4E (0.78) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL7265745 0.88 KDM4E (0.78) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL4393965 0.87 KDM4E (0.81) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL13388185 0.87 KDM4E (0.77) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL4388850 0.87 NPSR1 (0.75) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL13588883 0.87 NPSR1 (0.75) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL380893 0.86 PREP (0.57) NPSR1ALDH1A1TSHRKDM4ELMNA
SCHEMBL3011603 0.86 KDM4E (0.86) NPSR1ALDH1A1TSHRKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1637150-A Activities and ph tests for the determination of the risk of obstetric and gynecologic complications UNIBIO S R I (IT) 2005-07-13 CN claimed
US-20050095660-A1 Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women UNIBIO, S.R.I. (IT) 2005-05-05 US claimed
EP-1528396-A1 Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women UNIBIO S.R.L. (IT) 2005-05-04 EP claimed
US-20040219617-A1 Enzymatic test for the determination of the risk of pathologies related to the presence of sialidase or prolidase activity in women body fluid samples UNIBIO S.R.L. (IT) 2004-11-04 US claimed
EP-1360484-A1 ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES UNIBIO S.R.L. (IT) 2003-11-12 EP claimed
WO-2002065122-A1 ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES UNIBIO S.R.L. (IT) 2002-08-22 WO claimed
EP-1360484-B1 ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES UNIBIO S R L (IT) 2008-10-29 EP disclosed
CN-1637150-A Activities and ph tests for the determination of the risk of obstetric and gynecologic complications UNIBIO S R I (IT) 2005-07-13 CN disclosed
US-20050095660-A1 Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women UNIBIO, S.R.I. (IT) 2005-05-05 US disclosed
EP-1528396-A1 Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women UNIBIO S.R.L. (IT) 2005-05-04 EP disclosed
US-20040219617-A1 Enzymatic test for the determination of the risk of pathologies related to the presence of sialidase or prolidase activity in women body fluid samples UNIBIO S.R.L. (IT) 2004-11-04 US disclosed
EP-1360484-A1 ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES UNIBIO S.R.L. (IT) 2003-11-12 EP disclosed
WO-2002065122-A1 ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES UNIBIO S.R.L. (IT) 2002-08-22 WO disclosed
EP-0791071-B1 ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES LITMUS CONCEPTS INC (US) 1999-09-15 EP disclosed
EP-0791071-A1 ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES LITMUS CONCEPTS, INC. (US) 1997-08-27 EP disclosed
US-5571684-A SOLID PHASE CONJUGATE LITMUS CONCEPTS, INC. (US) 1996-11-05 US disclosed
WO-1996015255-A2 ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES LITMUS CONCEPTS, INC. (US) 1996-05-23 WO disclosed