Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.49 |
| ▸ | OXTR | P30559 | 10/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465521 | 0.86 | HCRTR1 (0.55) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4452216 | 0.83 | HCRTR1 (0.55) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4459174 | 0.83 | HCRTR1 (0.51) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4466283 | 0.82 | HCRTR1 (0.52) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL8247448 | 0.80 | HCRTR1 (0.51) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4467106 | 0.79 | HCRTR2 (0.54) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4462733 | 0.77 | HCRTR2 (0.59) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4457670 | 0.77 | HCRTR2 (0.63) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4459461 | 0.76 | HCRTR1 (0.45) | HCRTR1HCRTR2OXTRAVPR2AVPR1A | |
| SCHEMBL4459098 | 0.76 | HCRTR2 (0.60) | HCRTR1HCRTR2OXTRAVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912655-A2 | AMINOETHANE SULFONAMIDE OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007019234-A2 | AMINOETHANE SULFONAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-02-15 | — | — | WO | claimed |