Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.51 |
| ▸ | OXTR | P30559 | 15/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465521 | 0.89 | HCRTR1 (0.55) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL8250514 | 0.89 | CKS1B (0.42) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4466283 | 0.86 | HCRTR1 (0.52) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4459174 | 0.84 | HCRTR1 (0.51) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4452216 | 0.84 | HCRTR1 (0.55) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL8247320 | 0.82 | HCRTR2 (0.59) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4467106 | 0.82 | HCRTR2 (0.54) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4462733 | 0.82 | HCRTR2 (0.59) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4558123 | 0.80 | HCRTR1 (0.49) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 | |
| SCHEMBL4613644 | 0.80 | HCRTR1 (0.49) | HCRTR1HCRTR2OXTRAVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| WO-2007019234-A2 | AMINOETHANE SULFONAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPSR1 | HCRTR1 2/4885HCRTR2 1/4885OXTR 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.