SCHEMBL4614795

SCHEMBL4614795

O=C(O)C=CC(=O)OCC(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 12/20 0.47
TSHR P16473 2/20 0.33
TP53 P04637 1/20 0.33
EGLN1 Q9GZT9 1/20 0.33
EGLN3 Q9H6Z9 1/20 0.33
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
THRB P10828 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4614791 1.00 HCAR2 (0.47) HCAR2TSHRTP53EGLN1EGLN3
SCHEMBL4157246 0.93 HCAR2 (0.44) HCAR2TSHRTP53EGLN1EGLN3
SCHEMBL4156127 0.93 HCAR2 (0.44) HCAR2TSHRTP53EGLN1EGLN3
SCHEMBL6753132 0.92 HCAR2 (0.34) HCAR2TP53ALDH1A1ATM
SCHEMBL4614790 0.92 HCAR2 (0.34) HCAR2TP53ALDH1A1ATM
SCHEMBL4164061 0.89 HCAR2 (0.50) HCAR2TSHRTP53EGLN1EGLN3
SCHEMBL10457349 0.86 HCAR2 (0.48) HCAR2TSHRTP53EGLN1EGLN3
SCHEMBL11647883 0.85 THRB (0.35) HCAR2TP53ALDH1A1THRBATM
SCHEMBL6752099 0.85 THRB (0.35) HCAR2TP53ALDH1A1THRBATM
SCHEMBL14861342 0.83 HCAR2 (0.42) HCAR2TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1345074-B1 Silver halide photographic light-sensitive material comprising a hydrocarbon and a fluorinated surfactant FUJIFILM CORP (JP) 2008-02-20 EP disclosed
EP-1345074-A1 Silver halide photographic light-sensitive material comprising a hydrocarbon and a fluorinated surfactant FUJI PHOTO FILM CO., LTD. (JP) 2003-09-17 EP disclosed