Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309805 | 0.86 | GPBAR1 (0.60) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL1310065 | 0.84 | TSHR (0.63) | ALDH1A1KDM4EKMT2APOLBGAA | |
| SCHEMBL1308832 | 0.79 | HPGD (0.55) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL1308469 | 0.78 | GAA (0.53) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL1308444 | 0.73 | KCNMA1 (0.54) | KDM4EKMT2AMAPTNPSR1 | |
| SCHEMBL1308587 | 0.72 | GAA (0.52) | ALDH1A1LMNAKDM4EKMT2AGAA | |
| SCHEMBL1308040 | 0.70 | MEN1 (0.47) | ALDH1A1LMNAKMT2AMAPTHTT | |
| SCHEMBL1310239 | 0.70 | MAPT (0.43) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL1308138 | 0.70 | KCNMA1 (0.58) | ALDH1A1LMNAKDM4EKMT2APOLB | |
| SCHEMBL1308147 | 0.69 | GAA (0.44) | LMNAKMT2APOLBGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940792-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-1 AND/OR PIM-3 | Exelixis, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007044724-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-I AND/OR PIM-3 | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |