Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4615081 | 1.00 | ADRB2 (0.50) | ADRB2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4613866 | 0.94 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4613871 | 0.94 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4614250 | 0.94 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL5685792 | 0.94 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4614245 | 0.94 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4864873 | 0.92 | ADRB2 (0.54) | ADRB2 | |
| SCHEMBL4864861 | 0.92 | ADRB2 (0.54) | ADRB2 | |
| SCHEMBL4613101 | 0.89 | ADRB2 (0.52) | ADRB2 | |
| SCHEMBL4613084 | 0.89 | ADRB2 (0.52) | ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633714-B1 | 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS | PFIZER LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| EP-1633714-A1 | 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108675-A1 | 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |