Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4227282 | 1.00 | HSD17B10 (0.54) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL3578457 | 0.88 | GLA (0.70) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL3578454 | 0.88 | GLA (0.70) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL1969349 | 0.86 | GLA (0.57) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL4615244 | 0.86 | GLA (0.57) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL5031105 | 0.84 | HSD11B1 (0.55) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL5033309 | 0.81 | GLA (0.49) | HSD17B10GLAALDH1A1MEN1KMT2A | |
| SCHEMBL1970300 | 0.81 | GLA (0.49) | HSD17B10GLAALDH1A1MEN1KMT2A | |
| SCHEMBL4227278 | 0.79 | HSD11B1 (0.50) | HSD17B10GLAHSD11B1ALDH1A1MEN1 | |
| SCHEMBL3390856 | 0.78 | KMT2A (0.55) | HSD17B10HSD11B1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893606-A2 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006123255-A2 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | disclosed |