Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | TACR3 | P29371 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277219 | 0.89 | CTSB (0.42) | CTSBKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL3039920 | 0.88 | CTSB (0.61) | CTSBKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL3276524 | 0.88 | CTSB (0.42) | CTSBKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL3050935 | 0.85 | CTSB (0.63) | CTSBKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3050936 | 0.85 | CTSB (0.63) | CTSBKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3049466 | 0.85 | CTSB (0.49) | CTSBKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL3045951 | 0.83 | CTSB (0.66) | CTSBKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3045958 | 0.83 | CTSB (0.66) | CTSBKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3283641 | 0.82 | CTSB (0.44) | CTSBKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL13248865 | 0.79 | CTSB (0.82) | CTSBKDM4ESMN1; SMN2ALDH1A1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910347-A2 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | MEDIVIR AB (SE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007017144-A2 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | MEDIVIR AB (SE) | 2007-02-15 | — | — | WO | disclosed |