⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10583250 | 0.93 | GSR (0.40) | — | |
| SCHEMBL351207 | 0.85 | — | — | |
| SCHEMBL2516469 | 0.79 | — | — | |
| SCHEMBL2512164 | 0.78 | — | — | |
| SCHEMBL22401620 | 0.76 | — | — | |
| SCHEMBL22401617 | 0.76 | — | — | |
| SCHEMBL2510865 | 0.76 | CA1 (0.45) | — | |
| SCHEMBL18245473 | 0.76 | CA2 (0.40) | — | |
| SCHEMBL18245471 | 0.76 | CA2 (0.40) | — | |
| SCHEMBL10587194 | 0.76 | CACNA2D1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750724-A4 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | UNIV JOHNS HOPKINS (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1750724-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-02-14 | — | — | EP | disclosed |
| US-20050267077-A1 | Method for improving cognitive function by co-administration of a GABAB receptor antagonist and an acetylcholinesterase inhibitor | JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | US | disclosed |
| WO-2005112946-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | THE JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005112908-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050267076-A1 | Method for improving cognitive function | JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | US | disclosed |