Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815690 | 0.95 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDRAB9ANPC1LMNA | |
| SCHEMBL15969027 | 0.80 | MEN1 (0.63) | HPGDLMNAFFAR4THRATHRB | |
| SCHEMBL6811950 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDRAB9ANPC1LMNA | |
| SCHEMBL19124684 | 0.78 | LMNA (0.74) | SMN1; SMN2HPGDRAB9ANPC1LMNA | |
| SCHEMBL3085193 | 0.78 | MAPT (0.47) | SMN1; SMN2HPGDLMNAMAPTALDH1A1 | |
| SCHEMBL25922476 | 0.77 | GLRA1 (0.63) | SMN1; SMN2HPGDRAB9ANPC1LMNA | |
| SCHEMBL8843690 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2HPGDRAB9ANPC1LMNA | |
| SCHEMBL9823890 | 0.76 | KDM1A (0.50) | HPGDNPC1LMNAFFAR4THRA | |
| SCHEMBL10770964 | 0.76 | MEN1 (0.71) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL7809050 | 0.76 | KMT2A (0.57) | SMN1; SMN2HPGDRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915364-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007020388-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |
| EP-1718617-A2 | 3-SUBSTITUTED 1,5-DIPHENYLPYRAZOLE DERIVATIVES USEFUL AS CB1 MODULATORS3-SUBSTITUTED 1,5-DIPHENYLPYRAZOLE DERIVATIVES USEFUL AS CB1 MODULATORS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080343-A2 | 3-SUBSTITUTED 1,5-DIPHENYLPYRAZOLE DERIVATIVES USEFUL AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |