Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45311 | 0.99 | SMN1; SMN2 (0.41) | GRM5SMN1; SMN2PDE4BPDE4DKCNH2 | |
| SCHEMBL45748 | 0.91 | CYP1A2 (0.43) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL44385 | 0.88 | KMT2A (0.40) | SMN1; SMN2KCNH2MCHR1NPC1RAB9A | |
| SCHEMBL44578 | 0.84 | RAB9A (0.40) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL44170 | 0.83 | GAA (0.41) | SMN1; SMN2NPC1RAB9ATP53THRB | |
| SCHEMBL44476 | 0.81 | GAA (0.37) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL43913 | 0.81 | GAA (0.43) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL44367 | 0.80 | NPC1 (0.43) | SMN1; SMN2PDE4BPDE4DNPC1RAB9A | |
| SCHEMBL44764 | 0.78 | GAA (0.44) | TP53KMT2ATHRB | |
| SCHEMBL43972 | 0.78 | HTT (0.53) | SMN1; SMN2KCNH2TP53MAPK1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |