Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | ATIC | P31939 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MPL | P40238 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461763 | 0.96 | TNNI3 (0.42) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL21113847 | 0.96 | TNNI3 (0.42) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL95762 | 0.89 | TNNI3 (0.49) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL2776938 | 0.89 | MPL (0.47) | TNNI3TNNT2TNNC1HKDC1AURKA | |
| SCHEMBL217202 | 0.89 | MPL (0.47) | TNNI3TNNT2TNNC1HKDC1AURKA | |
| SCHEMBL10595679 | 0.89 | MPL (0.47) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL31344266 | 0.89 | MPL (0.47) | TNNI3TNNT2TNNC1HKDC1AURKA | |
| SCHEMBL11527283 | 0.87 | TNNI3 (0.48) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL19999157 | 0.87 | MPL (0.47) | TNNI3TNNT2TNNC1HKDC1ATIC | |
| SCHEMBL112192 | 0.86 | MPL (0.49) | TNNI3TNNT2TNNC1HKDC1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327149-B1 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | UNIV CALIFORNIA (US) | 2012-12-05 | — | — | EP | disclosed |
| WO-2002033044-A9 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | WO | disclosed |
| EP-2341346-A2 | Methods of high-throughput screening for internalizing antibodies and metal-chelating liposomes | The Regents of the University of California (US) | 2011-07-06 | — | — | EP | disclosed |
| EP-1327149-A4 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | UNIV CALIFORNIA (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060263801-A1 | Methods of high-throughput screening for internalizing antibodies | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-11-23 | — | — | US | disclosed |
| US-7045283-B2 | Methods of high-throughput screening for internalizing antibodies | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-05-16 | — | — | US | disclosed |
| EP-1327149-A2 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20020182643-A1 | Methods of high-throughput screening for internalizing antibodies | UNITED STATES GOVERNMENT, THE | 2002-12-05 | — | — | US | disclosed |
| WO-2002033044-A2 | METHODS OF HIGH-THROUGHPUT SCREENING FOR INTERNALIZING ANTIBODIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-25 | — | — | WO | disclosed |