SCHEMBL461816

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL470412	0.86	MAPT (0.40)	KDM4EGAAKDM5BMAPTPOLB
	SCHEMBL470433	0.86	KDM4E (0.41)	KDM4EGAAKDM5BMAPTPOLB
	SCHEMBL2051557	0.84	AURKA (0.46)	KDM4EGAAKDM5BMAPTPOLB
	SCHEMBL2040225	0.83	MAPT (0.39)	KDM4EGAAKDM5BMAPTPOLB
	SCHEMBL459359	0.82	MAPT (0.52)	KDM4EGAAMAPTPOLBALDH1A1
	SCHEMBL15475631	0.81	NPC1 (0.52)	KDM4EMAPTPOLBALDH1A1SMN1; SMN2
	SCHEMBL461080	0.79	DPP4 (0.52)	KDM4EMAPTPOLBALDH1A1SMN1; SMN2
	SCHEMBL2044748	0.78	KDM4E (0.42)	KDM4EGAAKDM5BMAPTPOLB
	SCHEMBL2045496	0.78	DPP4 (0.52)	KDM4EGAAMAPTPOLBALDH1A1
	SCHEMBL16271158	0.77	NPC1 (0.47)	KDM4EGAAMAPTPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.