SCHEMBL4618207

SCHEMBL4618207

CN(CCCNS(=O)(=O)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F)C(=O)N1CCN(C(=O)O)CC1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.56
WNT3 P56703 5/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4617980 0.95 SFRP1 (0.57) SFRP1WNT3
SCHEMBL4617858 0.92 SFRP1 (0.55) SFRP1WNT3
SCHEMBL4638096 0.91 SFRP1 (0.58) SFRP1WNT3
SCHEMBL4618070 0.89 SFRP1 (0.59) SFRP1WNT3
SCHEMBL4617698 0.89 SFRP1 (0.62) SFRP1WNT3
SCHEMBL4617315 0.87 SFRP1 (0.58) SFRP1WNT3
SCHEMBL4637519 0.86 SFRP1 (0.56) SFRP1WNT3
SCHEMBL4616867 0.86 SFRP1 (0.56) SFRP1WNT3
SCHEMBL4618232 0.86 SFRP1 (0.59) SFRP1WNT3
SCHEMBL4619024 0.83 SFRP1 (0.63) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879859-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF Wyeth a Corporation of the State of Delaware (US) 2008-01-23 EP disclosed
WO-2006124875-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF WYETH (US) 2006-11-23 WO disclosed