SCHEMBL4618758

SCHEMBL4618758

O=C(c1ccc(C(F)(F)F)nc1)N1CCC(NS(=O)(=O)c2ccccc2C(F)(F)F)CC1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.79
WNT3 P56703 4/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4732405 0.89 SFRP1 (0.77) SFRP1WNT3
SCHEMBL4616690 0.88 SFRP1 (1.00) SFRP1WNT3
SCHEMBL4786060 0.87 SFRP1 (0.69) SFRP1WNT3
SCHEMBL4734225 0.85 SFRP1 (0.64) SFRP1WNT3
SCHEMBL4733995 0.84 SFRP1 (0.63) SFRP1WNT3
SCHEMBL4735761 0.83 SFRP1 (0.63) SFRP1WNT3
SCHEMBL4736341 0.82 SFRP1 (0.61) SFRP1WNT3
SCHEMBL4736315 0.82 SFRP1 (0.61) SFRP1WNT3
SCHEMBL4671049 0.81 SFRP1 (0.86) SFRP1WNT3
SCHEMBL4616650 0.81 SFRP1 (1.00) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879859-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF Wyeth a Corporation of the State of Delaware (US) 2008-01-23 EP claimed
WO-2006124875-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF WYETH (US) 2006-11-23 WO claimed