⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352734 | 0.83 | — | — | |
| SCHEMBL4657208 | 0.82 | — | — | |
| SCHEMBL10439395 | 0.82 | ALDH1A1 (0.41) | — | |
| SCHEMBL10946107 | 0.81 | ALDH1A1 (0.38) | — | |
| Ethylene Glycol SCHEMBL6423323 | 0.80 | ALDH1A1 (0.40) | — | |
| SCHEMBL14660110 | 0.78 | — | — | |
| SCHEMBL5642292 | 0.78 | — | — | |
| SCHEMBL11213295 | 0.78 | — | — | |
| SCHEMBL28914169 | 0.78 | — | — | |
| SCHEMBL28743579 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273984-A | Bismuth complex having a carboxylic acid to form a salt of the basic antagonist excluding ranitidine | GLAXO GROUP LIMITED (GB) | 1993-12-28 | — | — | US | claimed |
| US-20230349922-A1 | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer | UNIVERSITÉ DE STRASBOURG (FR) | 2023-11-02 | — | — | US | disclosed |
| EP-4196793-A1 | H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER | Université de Strasbourg (FR) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022034121-A1 | H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER | UNIVERSITÉ DE STRASBOURG (FR) | 2022-02-17 | — | — | WO | disclosed |
| CN-106795127-A | Diamine compound, dinitro compound and other compounds and preparation method thereof and relative purposes | 微麦德斯公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106795127-A | Diamine compound, dinitro compound and other compounds and preparation method thereof and relative purposes | 微麦德斯公司 | 2017-05-31 | — | — | CN | disclosed |
| US-20160354342-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR. | SHAHID MUSLIM D (US) | 2016-12-08 | — | — | US | disclosed |
| US-9457011-B2 | Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor | SHAHID MUSLIM D (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150238463-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR | SHAHID MUSLIM D (US) | 2015-08-27 | — | — | US | disclosed |
| US-8277782-B2 | Antiinflammatory agent, metalloproteinase inhibitor, anti-oxidant and modifier of cell redox status, vitamins, inhibitor of activation of nuclear factor kappa beta | THE PROCTER & GAMBLE COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| EP-0001699-B1 | DERIVATIVES OF FURYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1982-02-24 | — | — | EP | disclosed |
| US-4288443-A | HISTAMINE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1981-09-08 | — | — | US | disclosed |
| US-4279819-A | GASTROINTESTINAL DISORDERS | ALLEN & HANBURYS LTD. (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4279819-A | GASTROINTESTINAL DISORDERS | ALLEN & HANBURYS LTD. (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4255440-A | ANTIALLERGENS, ANTIULCER AGENTS | ALLEN & HANBURYS LIMITED (GB) | 1981-03-10 | — | — | US | disclosed |
| US-4169855-A | ANTIHISTAMINES, ANTISECRETORY AGENTS | Allen & Hansbury, Limited (GB) | 1979-10-02 | — | — | US | disclosed |
| US-4169855-A | ANTIHISTAMINES, ANTISECRETORY AGENTS | Allen & Hansbury, Limited (GB) | 1979-10-02 | — | — | US | disclosed |
| EP-0001699-A2 | Derivatives of furyl compounds, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-05-02 | — | — | EP | disclosed |
| US-4128658-A | HISTAMINE ANTAGONISTS | ALLEN & HANBURYS LIMITED (GB) | 1978-12-05 | — | — | US | disclosed |
| US-4128658-A | HISTAMINE ANTAGONISTS | ALLEN & HANBURYS LIMITED (GB) | 1978-12-05 | — | — | US | disclosed |