Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DDO | Q99489 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.31 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586425 | 0.77 | GRM5 (0.36) | GRM5KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL1476965 | 0.77 | GRM5 (0.55) | GRM5KDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL1477130 | 0.76 | GRM5 (0.53) | GRM5KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL31139969 | 0.76 | ASIC3 (0.49) | ASIC3 | |
| SCHEMBL13379567 | 0.74 | GRM5 (0.43) | GRM5ASIC3 | |
| SCHEMBL13989092 | 0.74 | GRM5 (0.70) | GRM5DYRK1A | |
| Hydrochloric Acid SCHEMBL4865093 | 0.73 | GRM5 (0.68) | GRM5DYRK1A | |
| SCHEMBL1476753 | 0.70 | GRM5 (0.47) | GRM5 | |
| SCHEMBL15870986 | 0.69 | HDAC8 (0.39) | GRM5KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL503839 | 0.69 | KDM4E (0.34) | GRM5KDM4EMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893605-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006103449-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2006-10-05 | — | — | WO | disclosed |