SCHEMBL4619770

SCHEMBL4619770

Cc1nc2ncc(Br)cc2s1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.44
HRH3 Q9Y5N1 1/20 0.43
NPC1 O15118 3/20 0.41
HSD17B10 Q99714 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
RAB9A P51151 2/20 0.41
TP53 P04637 1/20 0.41
PKM P14618 1/20 0.41
HPGD P15428 1/20 0.41
HTT P42858 2/20 0.39
MAPK1 P28482 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
GAA P10253 1/20 0.38
DYRK1A Q13627 2/20 0.36
AURKA O14965 2/20 0.33
PAK4 O96013 2/20 0.33
CHEK1 O14757 1/20 0.33
DAPK3 O43293 1/20 0.33
JAK2 O60674 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7912720 0.80 SMN1; SMN2 (0.43) SMN1; SMN2NPC1HSD17B10ALDH1A1MAPT
SCHEMBL31296525 0.77 HRH3 (0.43) SMN1; SMN2HRH3ALDH1A1MAPTHTT
SCHEMBL2318862 0.77 NSD1 (0.47) SMN1; SMN2HRH3HSD17B10ALDH1A1MAPT
SCHEMBL7961498 0.77 HRH3 (0.43) SMN1; SMN2HRH3ALDH1A1MAPTHPGD
SCHEMBL2315498 0.77 HRH3 (0.43) SMN1; SMN2HRH3ALDH1A1MAPTHTT
SCHEMBL19061756 0.77 SMN1; SMN2 (0.50) SMN1; SMN2HRH3NPC1HSD17B10ALDH1A1
SCHEMBL14970107 0.77 HRH3 (0.43) SMN1; SMN2HRH3NPC1HSD17B10ALDH1A1
SCHEMBL21604598 0.77 SMN1; SMN2 (0.41) SMN1; SMN2NPC1HSD17B10ALDH1A1MAPT
SCHEMBL22333711 0.77 SMN1; SMN2 (0.41) SMN1; SMN2NPC1HSD17B10ALDH1A1MAPT
SCHEMBL19001707 0.77 SMN1; SMN2 (0.41) SMN1; SMN2NPC1HSD17B10ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080124732-A1 METHOD FOR OPTICAL MEASUREMENT OF MULTI-STRANDED NUCLEIC ACID FUJIFILM CORPORATION 2008-05-29 US disclosed
EP-1889880-A2 Method for optical measurement of multi-stranded nucleic acid FUJIFILM Corporation (JP) 2008-02-20 EP disclosed
EP-1362894-B1 Method for optical measurement of multi-stranded nucleic acid using cyanine dyes FUJIFILM CORP (JP) 2007-12-19 EP disclosed
US-20050112770-A1 Method for optical measurement of multi-stranded nucleic acid FUJI PHOTO FILM CO., LTD. 2005-05-26 US disclosed
EP-1362894-A2 Method for optical measurement of multi-stranded nucleic acid using cyanine dyes FUJI PHOTO FILM CO., LTD. (JP) 2003-11-19 EP disclosed