Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315498 | 1.00 | HRH3 (0.43) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 | |
| Hydrochloric Acid SCHEMBL2583689 | 0.98 | HRH3 (0.42) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 | |
| SCHEMBL745222 | 0.80 | HRH3 (0.44) | HRH3SMN1; SMN2DYRK1AKMT2AHTT | |
| SCHEMBL2318862 | 0.77 | NSD1 (0.47) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 | |
| SCHEMBL7961498 | 0.77 | HRH3 (0.43) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 | |
| SCHEMBL4619770 | 0.77 | SMN1; SMN2 (0.44) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 | |
| SCHEMBL1883389 | 0.77 | LTA4H (0.41) | HRH3LRRK2KMT2AALDH1A1MAPT | |
| SCHEMBL1883423 | 0.77 | KDM4E (0.39) | HRH3SMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL21206782 | 0.74 | KMT2A (0.41) | SMN1; SMN2KMT2AHTTALDH1A1MAPT | |
| SCHEMBL6339430 | 0.73 | HRH3 (0.40) | HRH3SMN1; SMN2DYRK1ADYRK1BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112805280-B | Heteroaryl compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-12-06 | — | — | CN | disclosed |