Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL195276 | 1.00 | FKBP5 (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| Proline SCHEMBL9803414 | 0.93 | OR51E2 (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| Proline SCHEMBL9803417 | 0.93 | OR51E2 (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| SCHEMBL3258686 | 0.84 | FKBP5 (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| Proline SCHEMBL11588329 | 0.83 | MEN1 (0.42) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL19349764 | 0.80 | BLM (0.50) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL19349766 | 0.80 | BLM (0.50) | MEN1BLMKMT2ADPP4DPP8 | |
| SCHEMBL23997628 | 0.78 | MEN1 (0.43) | MEN1BLMKMT2ADPP4DPP8 | |
| SCHEMBL6232294 | 0.78 | MEN1 (0.43) | MEN1BLMKMT2ADPP4DPP8 | |
| SCHEMBL6235834 | 0.78 | MEN1 (0.43) | MEN1BLMKMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896036-A1 | ANTI-INFLAMMATORY AGENTS | Cambridge Enterprise Limited (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006134384-A1 | ANTI-INFLAMMATORY AGENTS | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2006-12-21 | — | — | WO | disclosed |