Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 12/20 | 0.70 |
| ▸ | TLR2 | O60603 | 12/20 | 0.70 |
| ▸ | MAOA | P21397 | 9/20 | 0.68 |
| ▸ | MAOB | P27338 | 9/20 | 0.68 |
| ▸ | FBP1 | P09467 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619916 | 1.00 | TLR4 (0.70) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL2539612 | 0.84 | MAOA (0.70) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL1967344 | 0.83 | TLR4 (0.67) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL1967341 | 0.83 | TLR4 (0.67) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL510207 | 0.82 | TLR4 (1.00) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL510208 | 0.82 | TLR4 (1.00) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL510222 | 0.81 | MAOA (1.00) | TLR4TLR2MAOAMAOB | |
| SCHEMBL510223 | 0.81 | MAOA (1.00) | TLR4TLR2MAOAMAOB | |
| SCHEMBL18177331 | 0.81 | TLR4 (0.67) | TLR4TLR2MAOAMAOBFBP1 | |
| SCHEMBL510378 | 0.80 | TLR4 (1.00) | TLR4TLR2MAOAMAOBFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200120-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | LYCERA CORPORATION (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2008039882-A1 | A COMBINATION OF NIACIN AND A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST | SANOFI-AVENTIS U.S. LLC (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1891019-A2 | 2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006044732-A2 | 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-04-27 | — | — | WO | disclosed |