Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.63 |
| ▸ | HTR3A | P46098 | 2/20 | 0.63 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491922 | 1.00 | CHRNA7 (0.63) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL12338014 | 0.88 | CHRNA7 (0.61) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL5996761 | 0.85 | CHRNA7 (0.58) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL1964371 | 0.85 | CHRNA7 (0.58) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL1962888 | 0.84 | HTR3A (0.59) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL1965726 | 0.84 | HTR3A (0.59) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL492110 | 0.83 | CHRNA7 (0.54) | CHRNA7HTR3ABDKRB1HTR3EHTR3B | |
| SCHEMBL492614 | 0.83 | CHRNA7 (0.72) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL4602656 | 0.83 | CHRNA7 (0.72) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL260705 | 0.80 | CHRNA7 (0.74) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |