Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | MC1R | Q01726 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462004 | 1.00 | L3MBTL1 (0.47) | L3MBTL1KMT2ASCN9ANTRK1KDM1A | |
| SCHEMBL462010 | 0.93 | L3MBTL1 (0.45) | L3MBTL1KMT2ASCN9ANTRK1KDM1A | |
| SCHEMBL462009 | 0.93 | L3MBTL1 (0.45) | L3MBTL1KMT2ASCN9ANTRK1KDM1A | |
| SCHEMBL121388 | 0.91 | KMT2A (0.48) | L3MBTL1KMT2ACHRM4SIGMAR1DRD2 | |
| SCHEMBL1726613 | 0.91 | KMT2A (0.48) | L3MBTL1KMT2ACHRM4SIGMAR1DRD2 | |
| SCHEMBL143627 | 0.90 | MC1R (0.49) | L3MBTL1KMT2ASIGMAR1DRD2DRD3 | |
| SCHEMBL143625 | 0.90 | MC1R (0.49) | L3MBTL1KMT2ASIGMAR1DRD2DRD3 | |
| SCHEMBL143626 | 0.90 | MC1R (0.49) | L3MBTL1KMT2ASIGMAR1DRD2DRD3 | |
| SCHEMBL147672 | 0.90 | KMT2A (0.48) | L3MBTL1KMT2ACHRM4SIGMAR1DRD2 | |
| SCHEMBL147671 | 0.90 | KMT2A (0.48) | L3MBTL1KMT2ACHRM4SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |