Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 7/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18613336 | 0.82 | FYN (1.00) | FYNTGFBR1ACVR1 | |
| SCHEMBL2225829 | 0.82 | FYN (1.00) | FYNTGFBR1ACVR1 | |
| SCHEMBL2228058 | 0.79 | FYN (0.77) | FYNTGFBR1ACVR1 | |
| SCHEMBL2225805 | 0.78 | FYN (0.71) | FYNTGFBR1ACVR1KMT2AALDH1A1 | |
| SCHEMBL24681351 | 0.76 | FYN (0.68) | FYNTGFBR1ACVR1 | |
| SCHEMBL20485719 | 0.76 | FYN (1.00) | FYNTGFBR1ACVR1 | |
| SCHEMBL30521825 | 0.76 | FYN (1.00) | FYNTGFBR1ACVR1 | |
| SCHEMBL29914380 | 0.75 | FYN (0.67) | FYNTGFBR1ACVR1 | |
| SCHEMBL24680827 | 0.75 | FYN (0.67) | FYNTGFBR1ACVR1 | |
| SCHEMBL18613764 | 0.75 | FYN (1.00) | FYNTGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |