Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | PTAFR | P25105 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233435 | 0.91 | GNRHR (0.35) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4237773 | 0.90 | GNRHR (0.37) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4231634 | 0.90 | GNRHR (0.42) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4232911 | 0.89 | GNRHR (0.45) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4621730 | 0.87 | GNRHR (0.31) | GNRHR | |
| SCHEMBL4235977 | 0.87 | GNRHR (0.35) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL13743549 | 0.86 | GNRHR (0.35) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL13743102 | 0.85 | GNRHR (0.37) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4233369 | 0.84 | GNRHR (0.36) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL13743435 | 0.84 | GNRHR (0.35) | GNRHRCACNA1FCHRM4ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896465-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | Takeda Cambridge Limited (GB) | 2008-03-12 | — | — | EP | claimed |
| WO-2007000582-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2007-01-04 | — | — | WO | claimed |