Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4620898 | 1.00 | GPR84 (0.52) | GPR84FFAR1GRIK1GRIK2FFAR4 | |
| Propionic Acid SCHEMBL4622665 | 0.91 | GPR84 (0.52) | GPR84FFAR1GRIK1GRIK2FFAR4 | |
| Propionic Acid SCHEMBL4621325 | 0.91 | GPR84 (0.52) | GPR84FFAR1GRIK1GRIK2FFAR4 | |
| SCHEMBL10944400 | 0.90 | SPHK1 (0.50) | GPR84FFAR1MAPTCA2SPHK1 | |
| SCHEMBL5671085 | 0.90 | SPHK1 (0.50) | GPR84FFAR1MAPTCA2SPHK1 | |
| SCHEMBL10944404 | 0.90 | SPHK1 (0.50) | GPR84FFAR1MAPTCA2SPHK1 | |
| SCHEMBL4008504 | 0.90 | SPHK1 (0.50) | GPR84FFAR1MAPTCA2SPHK1 | |
| Glycolic Acid SCHEMBL10457251 | 0.89 | GPR84 (0.50) | GPR84FFAR1GRIK1GRIK2FFAR4 | |
| Hydrochloric Acid SCHEMBL5053423 | 0.88 | SPHK1 (0.48) | GPR84FFAR1MAPTCA2SPHK1 | |
| Bromide SCHEMBL10787697 | 0.88 | SPHK1 (0.48) | GPR84FFAR1MAPTCA2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648120-B2 | Liquid rheology modifier | KAO CORPORATION (JP) | 2014-02-11 | — | — | US | disclosed |
| US-20080078814-A1 | Liquid rheology modifier | KAO CORPORATION (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1897927-A2 | Liquid rheology modifier | Kao Corporation (JP) | 2008-03-12 | — | — | EP | disclosed |