Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365446 | 0.91 | KDM4E (0.46) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL2251277 | 0.84 | MMP2 (0.42) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL2249781 | 0.84 | MMP2 (0.39) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL2249366 | 0.83 | KDM4E (0.39) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL5651555 | 0.82 | KDM4E (0.51) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL2249344 | 0.82 | MMP2 (0.45) | KDM4EMMP2MMP9SLC1A5PDCD1 | |
| SCHEMBL2245100 | 0.82 | HPGD (0.41) | KDM4EMMP2SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL2248535 | 0.82 | SMN1; SMN2 (0.45) | MMP2SMN1; SMN2ADAMTS5MMP8MMP12 | |
| SCHEMBL2247537 | 0.82 | MMP2 (0.42) | KDM4EMMP2MMP9SLC1A5SMN1; SMN2 | |
| SCHEMBL2247715 | 0.81 | CYP3A4 (0.39) | KDM4EMMP2MAPTADAMTS5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |