Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170552 | 0.85 | HTR2C (0.54) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31329634 | 0.85 | HTR2C (0.54) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL754805 | 0.85 | HTR2C (0.54) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25356833 | 0.85 | SMN1; SMN2 (0.49) | PARP1NPC1RAB9ASMN1; SMN2CYP2C19 | |
| SCHEMBL25385249 | 0.85 | SMN1; SMN2 (0.49) | PARP1NPC1RAB9ASMN1; SMN2CYP2C19 | |
| SCHEMBL28202599 | 0.84 | PARP1 (0.48) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11179612 | 0.84 | NPC1 (0.51) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3155289 | 0.83 | PARP1 (0.53) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14630965 | 0.83 | PSEN1 (0.53) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20449099 | 0.83 | PARP1 (0.53) | PARP1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883636-A1 | SUBSTITUTED PIPERIDINE ANTAGONIST OF HI RECEPTOR TO BE USED FOR THE TREATMENT OF RHINITIS | GLAXO GROUP LIMITED (GB) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006125665-A1 | SUBSTITUTED PIPERIDINE ANTAGONIST OF HI RECEPTOR TO BE USED FOR THE TREATMENT OF RHINITIS | GLAXO GROUP LIMITED (GB) | 2006-11-30 | — | — | WO | disclosed |