SCHEMBL4621185

SCHEMBL4621185

CC(C)Oc1cc(Br)ccc1OCC(C)(C)[SiH](C)C

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 5/20 0.36
HRH4 Q9H3N8 2/20 0.35
HTT P42858 2/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
ALOX12 P18054 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PTGDR2 Q9Y5Y4 2/20 0.34
CCR5 P51681 1/20 0.33
NPY1R P25929 1/20 0.33
NPY2R P49146 1/20 0.33
RAB9A P51151 1/20 0.33
TSHR P16473 1/20 0.32
GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4816613 0.84 SMN1; SMN2 (0.42) HTTALDH1A1LMNASMN1; SMN2MAPT
SCHEMBL941193 0.81 GLA (0.42) HTTALDH1A1LMNASMN1; SMN2MAPT
SCHEMBL2287091 0.79 AAK1 (0.47) AAK1ALDH1A1LMNASMN1; SMN2POLB
SCHEMBL15208869 0.79 CYP2C9 (0.41) AAK1HTTALDH1A1LMNASMN1; SMN2
SCHEMBL15208753 0.78 AAK1 (0.38) AAK1HRH4HTTALDH1A1SMN1; SMN2
SCHEMBL22208677 0.78 TSHR (0.46) AAK1ALDH1A1LMNASMN1; SMN2POLB
SCHEMBL14992970 0.78 HTR2A (0.36) AAK1HTTALDH1A1LMNAPOLB
SCHEMBL6449279 0.77 CCR5 (0.52) HTTALDH1A1LMNASMN1; SMN2CCR5
SCHEMBL2863698 0.77 KMT2A (0.44) HTTALDH1A1LMNASMN1; SMN2MAPT
SCHEMBL15208943 0.75 HRH4 (0.35) AAK1HRH4HTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013016720-A2 NOVEL SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES GERINDA THERAPEUTICS, INC. (US) 2013-01-31 WO disclosed
EP-1896462-A2 SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES The Pfahl Family Trust (Dated 9 July 1996) (US) 2008-03-12 EP disclosed
WO-2006130613-A2 SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES THE PFAHL FAMILY TRUST (DATED 9 JULY 1996) (US) 2006-12-07 WO disclosed