Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.67 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516647 | 0.85 | CYP11B1 (0.60) | FYNMAP4K4CYP11B1CYP11B2MKNK1 | |
| SCHEMBL25366032 | 0.85 | CYP11B1 (0.60) | FYNMAP4K4CYP11B1CYP11B2MKNK1 | |
| SCHEMBL2226963 | 0.82 | FYN (0.70) | FYNCHEK2MAP4K4TGFBR1USP7 | |
| SCHEMBL18613347 | 0.81 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL30521707 | 0.81 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL18613256 | 0.75 | FYN (1.00) | FYNCHEK2MAP4K4USP7 | |
| SCHEMBL9936469 | 0.73 | CYP11B1 (0.57) | MAP4K4CYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL22084643 | 0.73 | MKNK1 (0.59) | MAP4K4CYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL4620276 | 0.73 | FYN (1.00) | FYNCHEK2MAP4K4TGFBR1USP7 | |
| SCHEMBL30521818 | 0.73 | FYN (1.00) | FYNCHEK2MAP4K4TGFBR1USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |