Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 12/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648872 | 0.88 | HCAR3 (0.64) | HCAR2HCAR3MMP1MMP2MMP9 | |
| SCHEMBL4648492 | 0.87 | HCAR2 (0.46) | HCAR2HCAR3DAOMMP1MMP2 | |
| SCHEMBL4647131 | 0.86 | HCAR2 (0.62) | HCAR2HCAR3MMP1MMP2MMP9 | |
| SCHEMBL4648305 | 0.85 | HCAR3 (0.58) | HCAR2HCAR3DAO | |
| SCHEMBL4647955 | 0.82 | TP53 (0.53) | HCAR3 | |
| SCHEMBL4648632 | 0.81 | HCAR3 (0.61) | HCAR2HCAR3DAO | |
| SCHEMBL4648554 | 0.81 | HCAR3 (0.61) | HCAR2HCAR3DAO | |
| SCHEMBL4648485 | 0.81 | HCAR2 (0.61) | HCAR2HCAR3DAO | |
| SCHEMBL4648283 | 0.79 | HCAR3 (0.61) | HCAR2HCAR3 | |
| SCHEMBL4649196 | 0.77 | HCAR3 (0.53) | HCAR2HCAR3MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | claimed |