Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.55 |
| ▸ | RXRA | P19793 | 3/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RXRG | P48443 | 3/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623612 | 0.96 | ITGB3 (0.57) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL4623073 | 0.92 | ITGB3 (0.74) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL1567864 | 0.86 | BACE1 (0.59) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL7349921 | 0.83 | ITGB3 (0.58) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL3450818 | 0.81 | ITGB3 (0.72) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL3451880 | 0.81 | ITGB3 (0.72) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL4623151 | 0.80 | MCHR1 (0.49) | ITGB3ITGA2BFFAR1BACE1CYP26A1 | |
| SCHEMBL4623199 | 0.79 | BACE1 (0.51) | ITGB3ITGA2BFFAR1RXRARXRB | |
| SCHEMBL4622569 | 0.78 | CA1 (0.59) | ITGB3ITGA2BCYP26A1MCHR1 | |
| SCHEMBL4622244 | 0.78 | ITGB3 (0.68) | ITGB3ITGA2BFFAR1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971878-B1 | AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-26 | — | — | EP | disclosed |
| US-7256204-B2 | Amine compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-14 | — | — | US | disclosed |
| US-6613805-B2 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-02 | — | — | US | disclosed |
| US-6310107-B1 | (+)-6-(4-BIPHENYLYL)METHOXY-2-(2-(N,N-DIMETHYLAMINO)ETHYL)TETR ALIN, OR A SALT IS USEFUL FOR INHIBITING PRODUCTION AND/OR SECRETION OF AMYLOID-BETA PROTEIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-30 | — | — | US | disclosed |