Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 16/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.66 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18613684 | 0.88 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL4621168 | 0.85 | CHEK2 (0.77) | FYNCHEK2TGFBR1 | |
| SCHEMBL2226987 | 0.85 | FYN (0.75) | FYNCHEK2TGFBR1CHEK1 | |
| SCHEMBL4620240 | 0.79 | CHEK2 (1.00) | FYNCHEK2CHEK1 | |
| SCHEMBL18613239 | 0.79 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL30521926 | 0.79 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL18613689 | 0.77 | FYN (1.00) | FYNCHEK2TGFBR1CHEK1 | |
| SCHEMBL12518226 | 0.77 | FYN (1.00) | FYNCHEK2TGFBR1CHEK1 | |
| SCHEMBL30521680 | 0.77 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL18613248 | 0.77 | FYN (1.00) | FYNCHEK2TGFBR1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |