Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.77 |
| ▸ | FYN | P06241 | 11/20 | 0.70 |
| ▸ | USP7 | Q93009 | 3/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620240 | 0.87 | CHEK2 (1.00) | CHEK2FYNMAP4K4 | |
| SCHEMBL4622183 | 0.85 | FYN (0.78) | CHEK2FYNTGFBR1 | |
| SCHEMBL18613684 | 0.82 | FYN (1.00) | CHEK2FYNTGFBR1 | |
| SCHEMBL18613239 | 0.82 | FYN (1.00) | CHEK2FYNTGFBR1ATRATM | |
| SCHEMBL30521926 | 0.82 | FYN (1.00) | CHEK2FYNTGFBR1ATRATM | |
| SCHEMBL2749503 | 0.76 | FYN (0.60) | CHEK2FYNTGFBR1ATRATM | |
| SCHEMBL2386262 | 0.76 | FYN (0.60) | CHEK2FYNKCNH2ATRATM | |
| SCHEMBL2226033 | 0.72 | FYN (0.76) | CHEK2FYNUSP7MAP4K4TGFBR1 | |
| SCHEMBL4898544 | 0.71 | FYN (0.49) | CHEK2FYNATRATM | |
| SCHEMBL12834048 | 0.71 | ATM (0.53) | CHEK2FYNATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |