Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL18875607 | 1.00 | — | — | |
| Proline SCHEMBL2939 | 1.00 | — | — | |
| Proline SCHEMBL6894672 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL718906 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL462225 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL10141181 | 1.00 | — | — | |
| Proline SCHEMBL13248912 | 1.00 | — | — | |
| Proline SCHEMBL10141185 | 1.00 | — | — | |
| D-Proline SCHEMBL21462052 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL6894675 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325063-C | L-amino acid water-soluble pearl powder and its preparing method | SONG TINGSHENG (CN) | 2007-07-11 | — | — | CN | claimed |
| CN-1709282-A | L-amino acid water-soluble pearl powder and its preparing method | SONG TINGSHENG (CN) | 2005-12-21 | — | — | CN | claimed |
| CN-118146298-A | Short peptide RQRG and application thereof in agriculture | 北方民族大学 | 2024-06-07 | — | — | CN | disclosed |
| US-20210054397-A1 | YIELD AND STRESS TOLERANCE IN TRANSGENIC PLANTS IV | MENDEL BIOTECHNOLOGY INC (US) | 2021-02-25 | — | — | US | disclosed |
| EP-3741853-A1 | METHODS OF CELL SELECTION AND MODIFYING CELL METABOLISM | Lonza Ltd. (CH) | 2020-11-25 | — | — | EP | disclosed |
| US-10787677-B2 | Yield and stress tolerance in transgenic plants IV | MENDEL BIOTECHNOLOGY, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| EP-3694477-A1 | TOPICAL PRODUCTS WITH A BIPHASIC SYSTEM | Cmed Aesthetics S.r.l. (IT) | 2020-08-19 | — | — | EP | disclosed |
| US-10724023-B2 | Microorganisms expressing modified glucoamylase enzymes | CARGILL, INCORPORATED (US) | 2020-07-28 | — | — | US | disclosed |
| US-10597667-B2 | Stress tolerance in plants | MENDEL BIOTECHNOLOGY, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20200048623-A1 | MODIFIED GLUCOAMYLASE ENZYMES AND YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED (US) | 2020-02-13 | — | — | US | disclosed |
| US-20190345471-A1 | LEADER-MODIFIED GLUCOAMYLASE POLYPEPTIDES AND ENGINEERED YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED (US) | 2019-11-14 | — | — | US | disclosed |
| WO-1994026249-A1 | COMPOSITIONS AND METHODS FOR REPARATION AND PREVENTION OF FIBROTIC LESIONS | MARGOLIN SOLOMON B (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5273885-A | Using a polyiodothyronine analog of a phenyl compound containing a hydroxyl group ortho to an iodine | SYNTEX (U.S.A.) INC. (US) | 1993-12-28 | — | — | US | disclosed |
| US-4376825-A | ENZYME-BOUND LIGANDS WITH FREE REACTIVE SITES WHICH CAN BIND RECEPTORS | SYVA COMPANY (US) | 1983-03-15 | — | — | US | disclosed |
| US-4282325-A | FOR AMPLIFICATION IN ASSAYS | SYVA COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4203802-A | ENZYME BOUND TO AN ESTROGEN LIGAND | SYVA COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4190496-A | RECEPTOR, LIGAND, AND ENZYME-BOUND | SYVA COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4067774-A | Compounds for enzyme amplification assay | SYVA COMPANY (US) | 1978-01-10 | — | — | US | disclosed |
| US-3975237-A | LIGANDS | SYVA COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
| US-3966556-A | Compounds for enzyme amplification assay methadone analogs | SYVA COMPANY (US) | 1976-06-29 | — | — | US | disclosed |