Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL10141185 | 1.00 | — | — | |
| Proline SCHEMBL7792 | 1.00 | — | — | |
| Proline SCHEMBL458825 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL18875607 | 1.00 | — | — | |
| Proline SCHEMBL146827 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL10141181 | 1.00 | — | — | |
| Proline SCHEMBL6894672 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL6894675 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| D-Proline SCHEMBL21462052 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL13248912 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146298-A | Short peptide RQRG and application thereof in agriculture | 北方民族大学 | 2024-06-07 | — | — | CN | disclosed |
| US-10724023-B2 | Microorganisms expressing modified glucoamylase enzymes | CARGILL, INCORPORATED (US) | 2020-07-28 | — | — | US | disclosed |
| US-20200048623-A1 | MODIFIED GLUCOAMYLASE ENZYMES AND YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED (US) | 2020-02-13 | — | — | US | disclosed |
| US-20190345471-A1 | LEADER-MODIFIED GLUCOAMYLASE POLYPEPTIDES AND ENGINEERED YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED (US) | 2019-11-14 | — | — | US | disclosed |
| US-10364421-B2 | Modified glucoamylase enzymes and yeast strains having enhanced bioproduct production | CARGILL, INCORPORATED (US) | 2019-07-30 | — | — | US | disclosed |
| US-10344288-B2 | Glucoamylase-modified yeast strains and methods for bioproduct production | CARGILL, INCORPORATED (US) | 2019-07-09 | — | — | US | disclosed |
| EP-3494129-A1 | LEADER-MODIFIED GLUCOAMYLASE POLYPEPTIDES AND ENGINEERED YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | Cargill, Incorporated (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20180094269-A1 | GLUCOAMYLASE-MODIFIED YEAST STRAINS AND METHODS FOR BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED | 2018-04-05 | — | — | US | disclosed |
| US-20180080014-A1 | MODIFIED GLUCOAMYLASE ENZYMES AND YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED | 2018-03-22 | — | — | US | disclosed |
| WO-2018027131-A1 | LEADER-MODIFIED GLUCOAMYLASE POLYPEPTIDES AND ENGINEERED YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION | CARGILL, INCORPORATED (US) | 2018-02-08 | — | — | WO | disclosed |
| US-8269037-B2 | Absorption medium for removing acid gases which comprises amino acid and acid promoter | BASF SE (DE) | 2012-09-18 | — | — | US | disclosed |
| EP-2449488-A1 | METHOD FOR NORMALIZATION IN METABOLOMICS ANALYSIS METHODS WITH ENDOGENOUS REFERENCE METABOLITES | BIOCRATES Life Sciences AG (AT) | 2012-05-09 | — | — | EP | disclosed |
| US-20120051989-A1 | REMOVAL OF ACID GASES FROM A FLUID FLOW BY MEANS OF REDUCED COABSORPTION OF HYDROCARBONS AND OXYGEN | BASF SE (DE) | 2012-03-01 | — | — | US | disclosed |
| US-8034166-B2 | Carbon dioxide absorbent requiring less regeneration energy | BASF SE (DE) | 2011-10-11 | — | — | US | disclosed |
| US-7964630-B2 | Topical application agents against mimic and age-related wrinkles | DSM IP ASSETS B.V. (NL) | 2011-06-21 | — | — | US | disclosed |
| US-7927621-B2 | Thioester-ester-amide copolymers | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-7883200-B2 | Electrophotographic ink jet printing on alkaline sized paper containing additive such as 2-pyrrolidone carboxylic acid; rapid drying; reduced bleeding and feathering | FUJI XEROX CO., LTD. (JP) | 2011-02-08 | — | — | US | disclosed |
| WO-2011000753-A1 | METHOD FOR NORMALIZATION IN METABOLOMICS ANALYSIS METHODS WITH ENDOGENOUS REFERENCE METABOLITES | BIOCRATES LIFE SCIENCES AG (AT) | 2011-01-06 | — | — | WO | disclosed |
| US-20100186590-A1 | ABSORPTION MEDIUM FOR REMOVING ACID GASES WHICH COMPRISES AMINO ACID AND ACID PROMOTER | BASF SE (DE) | 2010-07-29 | — | — | US | disclosed |
| US-6835808-B2 | Synthetic oligopeptide heparin-neutralizing agents including basic amino acids and a N-heterocyclic end group; low turbidity; side effects reduction; in vitro diagnosis; calculate the blood clotting time; assaying clotting cascade | DIAGNOSTICA-STAGO (FR) | 2004-12-28 | — | — | US | disclosed |