Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 7/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147474 | 0.81 | ABCG2 (0.60) | PIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4140239 | 0.77 | PIK3CA (0.55) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4139135 | 0.74 | PIK3CA (0.74) | PIK3CAPIK3CGPIK3CBPIK3CDHTT | |
| SCHEMBL15299524 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CGPIK3CBPIK3CDHTT | |
| SCHEMBL4138246 | 0.71 | PIK3CA (0.67) | PIK3CAPIK3CGPIK3CBPIK3CDHTT | |
| SCHEMBL1311387 | 0.71 | PIK3CA (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDHTT | |
| SCHEMBL5172881 | 0.70 | PIK3CA (1.00) | PIK3CAPIK3CGPIK3CBPIK3CDHTT | |
| SCHEMBL28871764 | 0.70 | PIK3CA (0.55) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL1311669 | 0.70 | PIK3CA (0.82) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4138270 | 0.69 | ALDH1A1 (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945627-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | LUDWIG INSTITUTE FOR CANCER RESEARCH (CH) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042806-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | LUDWIG INSTITUTE FOR CANCER RESEARCH (CH) | 2007-04-19 | — | — | WO | disclosed |